foto_presidente Professor Ivan Izquierdo is one of the most productive and influential Brazilian neuroscientists. He was born in Argentina, where he graduated in Medicine (1961) and received his PhD in Pharmacology (1963) at the Universidad de Buenos Aires. He worked at the Universidad Nacional de Cordoba for nearly one decade, but for political and personal reasons he moved with his wife to Brazil. He became a Full Professor at Escola Paulista de Medicina, in São Paulo, where he stayed for a few years, and later moved to Porto Alegre in 1978; he got the Brazilian citizenship in 1981. For more than 20 years Professor Izquierdo directed the Center of Memory at the Biochemistry Department of the Universidade Federal do Rio Grande do Sul, where he supervised more than 40 PhDs on topics of neurobiology of learning and memory. After retirement, he was appointed to the Pontifícia Universidade Católica (PUCRS) where he continues on research. Professor Izquierdo’s main contributions are on the fields of memory consolidation and retrieval modulation, particularly the roles of endogenous opioid peptides, cathecolamines and acetylcholine systems, as well as the participation of GABAergic neurons, in the mammalian brain. His experimental work on endogenous state dependency and physiology of short- and long-term memory has influenced generations of basic and clinical neuroscientists. He is also a writer, having published six fiction and chronicle books.

In four decades of an intense and creative career, Professor Izquierdo has published more than 580 papers that received around 20,000 citations; 20+ of his articles received more than 100 citations each, what makes him one of the most cited Brazilian and Latin American scientists ever. He is nationally and internationally recognized for his contributions and decisive role for development of neurosciences, being awarded more than 60 prizes and distinctions, including the titles of Doctor Honoris Causa of Argentinean and Brazilian Universities, the Conrado Wessel Prize and the Rio Branco Order of the Brazilian Republic. He participates in more than 20 scientific societies and is a member of the Brazilian Academy of Sciences, the National Academy of Sciences of the USA and the Third World Academy of Sciences.

Selected papers:

. I Izquierdo (1979) Effect of naloxone and morphine on various forms of memory in the rat – possible role of endogenous opiate mechanisms in memory consolidation. Psychopharmacology, 66, 199-203.

. I Izquierdo, DO Souza, RD Dias, MLS Perry, MA Carrasco, N Volkmer, CA Netto (1984) Effect of various forms of training and testing procedures on brain beta-endorphin-like immunoreactivity and the possible role of beta-endorphin in behavioral regulation. Psychoneuroendocrinology, 9, 381-389.

. I Izquierdo, C da Cunha, R Rosat, D Jerusalinsky, MB Ferreira, JH Medina (1992) Neurotransmitter receptors involved in post-training memory processing by the amygdale, medial septum and hippocampus of the rat. Behavioral and Neural Biology, 58, 16-26.

. I Izquierdo, JH Medina (1997) Memory Formation: The sequence of biochemical events in the hippocampus and its connection to activity in other brain structures. Neurobiology of Learning and Memory, 68, 285-316.

. I Izquierdo, DM Barros, T Mello e Souza, MM Souza, LA Izquierdo, JH Medina (1998) Mechanisms for memory types differ. Nature, 393, 635-636.

. WC Da Silva, G Cardoso, JS Bonini, F Benetti, I Izquierdo (2013) Memory reconsolidation and its maintenance depend on L-voltage-dependent calcium channels CaMKII functions regulating protein turnover in the hippocampus. Proceedings of the National Academy of Sciences USA, 110, 6566-6570.

. PB Mello-Carpes, I Izquierdo (2013) The Nucleus of the Solitary Tract→Nucleus Paragigantocellularis→Locus Coeruleus→CA1 region of dorsal hippocampus pathway is important for consolidation of object recognition memory. Neurobiology of Learning and Memory, 100, 56-63.

. JC Myskiw, F Benetti, I Izquierdo (2013) Behavioral tagging of extinction learning. Proceedings of the National Academy of Sciences USA, 110, 1071-1076.

. JC Myskiw, C Furini, F Benetti, I Izquierdo (2014) Hippocampal molecular mechanisms involved in the enhancement of fear extinction caused by exposure to novelty. Proceedings of the National Academy of Sciences USA, 111, 4572-4577.